Alkaline phosphatase: reference interval transference from CALIPER to a pediatric Brazilian population
نویسندگان
چکیده
منابع مشابه
Pediatric Population Reference Value Distributions for Cancer Biomarkers: A CALIPER Study of Healthy Community Children
As part of CALIPER program, a national research initiative aimed at closing the gaps in pediatric reference intervals, I sought to develop a database of covariate-stratified reference intervals in children for 11 circulating tumor markers in accordance with CLSI C28-A3 guidelines. Healthy children from birth to 18 years were recruited to participate in CALIPER and serum samples from 400-700 sub...
متن کاملPediatric population reference value distributions for cancer biomarkers and covariate-stratified reference intervals in the CALIPER cohort.
BACKGROUND Cancer biomarkers are commonly used in pediatrics to monitor cancer progression, recurrence, and prognosis, but pediatric reference value distributions have not been well established for these markers. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) sought to develop a pediatric database of covariate-stratified reference value distributions for 11 key ci...
متن کاملA Description of Reference Ranges for Organic Acids in Urine Samples from A Pediatric Population in Iran
Background: Organic acids refer to a family of compounds that are intermediates in a variety of metabolic pathways. Many organic acids are present in urine from clinically normal individuals. Elevated levels of urine organic acids cause to the organic acidurias, disorders in which some metabolic pathways in organic acid metabolism are blocked. The present work identified major and minor urinary...
متن کاملDevelopment of a reference material for alkaline phosphatase.
In developing a Reference Material for alkaline phosphatase, we studied the stability, kinetic properties, and commutability of separate preparations of the purified enzyme from human liver, intestine, bone, and placenta. The Michaelis constants (Km) for the preparations from liver, bone, and intestine agreed well with the Km values we obtained for five human serum specimens, whereas that for t...
متن کاملPhosphate Binding to Alkaline Phosphatase
The metal ion dependence of a2P binding to Escherichia coli alkaline phosphatase has been studied by means of equilibrium dialysis. Whereas the apoenzyme does not bind phosphate (no sites with K < 5 X 10-5 M), the addition of 2 Zn(I1) cations per molecule induces the tight binding of 1 phosphate dianion (K = 6 X 1OF M). The magnitude of this binding constant is affected by ionic strength, pH, a...
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ژورنال
عنوان ژورنال: Jornal Brasileiro de Patologia e Medicina Laboratorial
سال: 2018
ISSN: 1676-2444
DOI: 10.5935/1676-2444.20180039